Treatment of Myasthenia Gravis Based on Its Immunopathogenesis
نویسندگان
چکیده
منابع مشابه
Treatment of Myasthenia Gravis Based on Its Immunopathogenesis
The prognosis of myasthenia gravis (MG) has improved dramatically due to advances in critical-care medicine and symptomatic treatments. Its immunopathogenesis is fundamentally a T-cell-dependent autoimmune process resulting from loss of tolerance toward self-antigens in the thymus. Thymectomy is based on this immunological background. For MG patients who are inadequately controlled with suffici...
متن کاملO 29: Autoimmune Myasthenia Gravis Introduction, Immunopathogenesis and Classification
Autoimmune Myasthenia Gravis (MG) is a unique disease among all autoimmune disorders in two ways. First, there are a wide range of sub-specialties involved in the diagnosis and management of MG; secondly MG is an autoimmune disorder whose autoimmunity is well established. In this paper I will cover these topics: history and epidemiology of MG followed by a brief overview on physiology of neurom...
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Myasthenia gravis (MG) and neuromyelitis optica (NMO) are autoimmune channelopathies of the peripheral neuromuscular junction (NMJ) and central nervous system (CNS) that are mainly mediated by humoral immunity against the acetylcholine receptor (AChR) and aquaporin-4 (AQP4), respectively. The diseases share some common features, including genetic predispositions, environmental factors, the brea...
متن کاملTreatment of myasthenia gravis.
Myasthenia gravis is a prototypic antibody-mediated neurological autoimmune disorder. Its pathogenesis is much better understood than that of multiple sclerosis or immune neuropathies. Currently two targets in the endplate membrane are considered as autoantigens, the acetylcholine receptor (in up to 90%) and the muscle-specific kinase (MuSK, in about 5%). Fortunately, substantial therapeutic pr...
متن کاملo 29: autoimmune myasthenia gravis introduction, immunopathogenesis and classification
autoimmune myasthenia gravis (mg) is a unique disease among all autoimmune disorders in two ways. first, there are a wide range of sub-specialties involved in the diagnosis and management of mg; secondly mg is an autoimmune disorder whose autoimmunity is well established. in this paper i will cover these topics: history and epidemiology of mg followed by a brief overview on physiology of neurom...
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ژورنال
عنوان ژورنال: Journal of Clinical Neurology
سال: 2011
ISSN: 1738-6586,2005-5013
DOI: 10.3988/jcn.2011.7.4.173